Lab devices for particle analytics from BRAVE Analytics

We built our BRAVE particle analysis devices as a modular platform which can be configured to suit your requirements. Talk to us about your challenges and we will find the best solution for you. BRAVE instruments can be upgraded with additional modules at a later date. We can also support you in coupling them to your existing instrumentation. Get in touch!

BRAVE lab devices in action

How can we help you?

The appearance of unexpected and unwanted large particles might ruin a whole batch or production run, wasting time and resources and causing financial losses. 

BRAVE Analytics provides continuous, in-flow, large-volume scans with single-particle sensitivity so even low concentrations of contaminants are found.

Choose the module to cover your size range within 5 nm to 80 µm* and look forward to a more relaxed approach to production. We provide both online PAT sensors as well as benchtop analyzers for the lab.

Adding an additional Raman analyzer lets you identify the contaminants so you can troubleshoot your process and discover the source of the problem.

Your processes are time-sensitive? Then  it makes no sense to spend hours waiting for results from the lab.

Remove this painful bottleneck by checking on e.g. fermentation progress in just minutes every hour or monitor changes in particle populations directly online 24/7.

Monitor:

  • homogenization processes
  • fermentation progress
  • onset of aggregation
  • contaminants
  • lipoproteins, proteins, ligands, antibodies and more

You have regulations and standards to uphold for your particle systems?

The BRAVE devices help you achieve smooth-running production with no headaches by providing particle sizing from 5 nm to 80 µm*.

With an additional Raman module you can identify single particles and populations. 

Benefit from:

  • full size histograms
  • single-particle sensitivity
  • small-particle monitoring (aggregation behavior)
  • large-particle monitoring (e.g. for PFAT5 evaluation)

Comparison of
BRAVE particle analysis devices and modules

Device name Particle range (sample-dependent) Technology Available as lab device Available as PAT sensor
50 nm to 3 µm*
OF2i®
yes
yes
5 nm to 50 nm*
Static Light Scattering
yes, as a software extension of BRAVE B-Curious
yes, as a software extension of BRAVE B-Curious PAT sensor
1 µm to 50 µm*
(600 nm LOD for polymers)
Raman spectroscopy
yes
yes, for bulk signal analysis
2 µm to 80 µm*
Orthogonal Inline Microscopy/ Obscuration
yes
yes

*sample-dependent

Take a closer look at the configurations of
our BRAVE particle analysis modules for the laboratory

Configuration of the setup:
BRAVE B-Curious device with OF2i® detector module, Fluid Automation Module, Control and Evaluation Module & Software

BRAVE B-Curious

Particle sizing, PSD determination

BRAVE B-Curious determines the particle size distributions of polydisperse systems with single-particle sensitivity.

Delivers automated, continuous and time-resolved results.

Detects ultra-low particle concentrations as well as large-particle tails, LPC, anomalies and outliers. 

Can be expanded with other modules (B-Aware software module, B-Elementary OF2i-Raman detector module).

  • Detection range

    50 nm to 3 µm*

  • Concentration range

    optimal: 106 particles/ml to 1010 particles/ml

  • Particles measured per minute

    Up to 1000 particles per minute*

*sample-dependent

Configuration of the setup:
BRAVE B-Curious device with OF2i® detector module, Fluid Automation Module, Control and Evaluation Module & Software

BRAVE B-Aware Software-Module (beta version)

Detection of small particle signals

The BRAVE B-Aware software module is an optional extension for BRAVE B-Curious and currently available as beta version.

The BRAVE B-Aware module detects the scattering signal of very small particles (from 5 nm*) and delivers the overall intensity as a bulk signal.

Ideal for detecting the onset of aggregation and tracking sample behavior when very small particles are involved.

Continuous in-flow measurement.

  • Detection range

    5 nm to 50 nm*

  • Concentration range

    Sample-dependent

  • Particles detected per minute

    Over 1000 particles per minute (sample-dependent)

*sample-dependent

 

Configuration of the setup:
BRAVE B-Elementary with OF2i® detector module, OF2i®-Raman detector module, Fluid Automation Module, Control Evaluation Module & Software

BRAVE B-Elementary

In-flow Raman analytics

Built on the proven BRAVE B-Curious platform, the BRAVE B-Elementary adds Raman spectroscopy for particle identification.

The BRAVE B-Elementary detects and identifies particles (<1 µm*) and microplastics (1 µm to 50 µm*) using Raman spectroscopy.

Automated measurement and minimum sample preparation for user-independent results.

Continuous in-flow measurement, ideal for detecting low particle concentrations, even with fluorescent substances.

  • Detection range

    Nanoparticles (<1 µm*) and microplastics (1 µm to 50 µm*)

  • Concentration range

    Sample-dependent (including ultra-low concentrations)

  • Particles detected per minute

    Approx. 100 particles per minute*

*sample-dependent

 

Configuration of the setup:
BRAVE B-Phat with OIM detector module, Fluid Automation Module, Control and Evaluation Module & Software

BRAVE B-Phat Base Station

Large particle detection

The BRAVE B-Phat device detects and sizes large particles based on dynamic imaging and obscuration principles.

Can be used to assess PFAT5 values, detect large aggregates, large-particle tails and anomalies.  

Also useful for predictive maintenance.

  • Detection range

    2 µm to 80 µm*

  • Concentration range

    dependent on particle size

  • Particles detected per minute

    dependent on particle size

*sample-dependent

Modules for sample handling

Every BRAVE system requires a Fluid Automation Module. Optional BRAVE B-Prepared dilution units can be tailored to your sample and process requirements.

  • BRAVE B-Prepared

    Automated sample preparation device for automated dilution before PSD / LPC determination

  • BRAVE Fluid Automation Module

    For automated liquid handling and cleaning

  • Tailored solutions

    Standard and custom-tailored versions available on request

BRAVE PAT sensors

All BRAVE technologies are available as PAT sensors for continuous process monitoring.

Applications include biotech formulations, pharmaceuticals, cosmetics, semiconductor manufacturing and polymer production.

  • Particle sizing and PSD

    50 nm* to 3 µm*

  • Small particle monitoring

    5 nm* to 50 nm*

  • Large-particle detection, PFAT5

    approx. 2 µm* to 80 µm*

  • In-flow Raman analysis

    Nanoparticles (<1 µm*) and microplastics (1 - 50 µm*)

*sample-dependent