Large particle detection

Detecting and sizing large particles in flow

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Large particle detection is an essential part of quality control and production monitoring in many manufacturing processes. The BRAVE large particle detector helps you ensure the highest product quality – and gives you valuable insights for troubleshooting potential problems.

The device is also available as a PAT sensor for 24/7 production monitoring online.

Don't let large particles spoil your day

Unwanted large particles or aggregates in your product are a disaster waiting to happen. To avoid losing batches or ruining the whole production day, BRAVE B-Phat is your tireless worker ready to warn you as soon as any large particles are discovered.

Ideal for pharmaceutical production

BRAVE B-Phat was originally developed as the solution for adhering to the PFAT5 regulations. It is a powerful tool and rises to the challenge of the strict requirements of pharmaceutical production. Whether you are using the lab device or the online PAT sensor, BRAVE B-Phat helps you eliminate the risk of out-of-spec production - without long waiting times or the stress of unreliable offline methods.

BRAVE B-Phat large particle detector for continuous in-flow analysis of particles

This is one frame image from a full video of a measurement. It shows how each passing particle is detected and given an ID tag. The software simultaneously evaluates the size of each detected particle and creates continuously updated histograms.

How does BRAVE B-Phat work?

BRAVE B-Phat pumps sample continuously through a sample cell with a powerful light source focused through it.

The device records a video of the sample passing through the sample cell based on dynamic image analysis principles. Tailored algorithms are used to evaluate the video images.

Specifications of BRAVE B-Phat (lab device)

Disrupting conventional approaches to large particle sizing:
this benchtop large particle detector brings a previously unseen capability for continuous measurement on sample in a flow-through cell
Based on light obscuration:
and evaluated using dynamic imaging principles
Saves you time:
with the automated dilution you get results quicker than with conventional methods
Relevant and reliable results:
measure continuously to track changes in real-time; proven throughput up to 1000 particles/minute, measurement over minutes up to hours
Particle range:
from 2 µm to 80 µm (sample-dependent)
No-hassle cleaning:
an automated self-cleaning cycle cleans the device in just 30 seconds
Analyze particle size, particle size distribution, particle concentration, particle count per milliliter, predominant aspect ratio factors (with further shape statistics available on request)
Made to scale up:
using the same measuring principles and routines, the BRAVE B-Phat device is available as a PAT sensor for direct production monitoring

Too good to be true?

A continuous measurement in a lab instrument?
Single-particle sensitivity?
Additional small-particle or Raman analysis?
You've never heard of it before and yet the real-time insights from this new approach could save you money and greatly improve your particle processes. Check out how our BRAVE devices are helping these customers in research and industry.
For more information, contact us or book a live demonstration and we will answer all your questions.

BRAVE products for a BRAVE world

Overview of BRAVE modules and sensors

The BRAVEst modules of them all

Time-resolved PSD and particle sizing

Allows the monitoring of PSD continuously and directly out of containers. Ideal for monitoring agglomeration, formation, dissolution, aggregation, dissociation, self-assembly and more. Size range: 50 nm* to 5 µm* (*sample-dependent)

Particle concentration and particle counts

Allows the detection of small particles from approx. 5 nm to 50 nm. Gives insight into agglomeration and aggregation behavior.

Large-particle tails & PFAT5

Allows the detection and sizing of large-particle tails, LPC, large aggregates and anomalies. Also for PFAT5 detection. Size range: 2 µm* to 60 µm* (*sample-dependent)

Raman analytics

Allows the detection, identification and characterization of particle populations via Raman spectroscopy.

Modules for sample handling

To make your life easier, use the BRAVE modules for automatic sample handling and sample dilution.

PAT solutions

For 24/7 production monitoring BRAVE Analytics provides custom-tailored online solutions.