Benchtop particle characterization
Investigating particle count, size distribution and particle concentration
Are you interested in:
Whether you are manufacturing semiconductors or producing pharmaceuticals, cosmetics or biotech formulations, time-resolved measurement of your product’s particle parameters with the BRAVE benchtop analyzers helps you safeguard your product quality – and gives you valuable data to improve your production processes.
For research and product development, the BRAVE devices give you a fast track to better understanding particle systems and the processes at work in your samples.
There is a BRAVE benchtop setup to suit your requirements. Are you looking to investigate small (nano)particles or larger particles?
To investigate and determine particle size and particle size distributions use BRAVE Analytics' OF2i® device, BRAVE B-Curious.
To monitor particle counts and track changes in particle concentration, use BRAVE Analytics combined OF2i®-SPLS (single-particle light scattering) device, BRAVE B-Curious with B-Aware module.
BRAVE B-Curious particle analyzer with optional module BRAVE B-Aware for extended analysis on small particles
Strengths of BRAVE particle analyzers
The continuous in-flow OF2i® measurement with single-particle accuracy provides detailed insights into all the particle populations of your sample and allows you to track changes in particle size and particle concentrations so as to keep on top of e.g. homogenization steps and other processes involving strict requirements for particle size distribution.
And prepare to be surprised: conventional methods of particle analysis like DLS, NTA or Laser Diffraction only show a fraction of what the patented OF2i® method reveals. With OF2i® you will get a better understanding of your particles’ sizes and behavior, and learn more about the processes involved.
Stop out-of-spec production happening
Whether you are manufacturing medical formulations, cosmetics or semiconductor wafers, what really hurts is to waste valuable time and resources on out-of-spec product. Directly monitoring production with the option to respond to negative changes immediately is essential. This may be via a PAT sensor or implementing reliable QC in the lab or at-line.
Turnaround time is critical. BRAVE devices deliver the right results quickly.
Investing in new technology with more depth of analysis is a good way to keep ahead of the competition. The future is here before you know it.
Previously unseen capabilities of BRAVE devices:
Take the guesswork out of fermentation processes
Don't let a batch spoil while waiting for results from the lab. Connect a BRAVE particle device to your reactor and analyze a few microliters per hour to instantly get a window into cell growth and protein expression.
You can now make informed decisions about the best time to harvest, minimize product heterogeneity and aggregation levels.
BRAVE devices deliver the right results to keep you in the loop.
Keep on top of changes in your particle systems and take the guesswork out of e.g. fermentation or emulsion polymerization processes. As it delivers data points every second, the BRAVE B-Aware module for BRAVE B-Curious base station is ideal for monitoring the behavior of particle systems which tend to agglomerate quickly. If you want to stop a process before monomers suddenly become too many dimers, trimers or fibrils, monitoring the particle count and particle concentration continuously and in real-time is now reality.
Working alongside BRAVE B-Curious to deliver complementary insights, the additional module BRAVE B-Aware opens the door to observing small particles down to 5 nm. With data from BRAVE B-Aware you can detect and take advantage of the ideal time to stop a process in order to get the best end product and avoid costly mistakes during production.
Which setup is best for you?
BRAVE B-Curious with or without BRAVE B-Aware?
Do you need particle size distribution (PSD) values?
>> BRAVE B-Curious
Are you interested in sample behavior such as dissolution, dissociation, condensate formation, crystallization and protein-protein interactions? >> BRAVE B-Curious (or BRAVE B-Aware for small particles)
Do you want to detect the onset of aggregation, agglomeration or other process? >> BRAVE B-Aware
Do you want to detect ultra-low particle concentrations (a few particles per milliliter)? >> BRAVE B-Curious
Do you need particle sizing with single-particle sensitivity? >> BRAVE B-Curious
SIZE RANGE
Particle sizing from approx. 50 nm to 3 µm (sample-dependent)
MEASUREMENT PRINCIPLE
Uses the patented OF2i® principle of continuous particle sizing
SETUP
SIZE RANGE
Particle sizing from approx. 5 nm to 50 nm (sample-dependent)
MEASUREMENT PRINCIPLE
Uses single-particle light scattering (SPLS); detects and evaluates the intensity signals of the light scattered by individual particles
SETUP
The BRAVE particle analyzers give you a new in-depth, single-particle analysis with the capability to monitor sample behavior as it happens in the flow cell. Besides the standard generated measuring report you also get access to the raw data and live stream video. We can advise on how to interpret data, just get in touch. See how our devices are involved in groundbreaking research in the field of nanoparticle characterization.
Browse our scientific publications
Would you like to learn more about the theoretical background of the BRAVE technologies, their proof-of-concepts and exciting hyphenation with other techniques?
Take a look at our scientific papers.
We built the BRAVE modular platform, so you can configure it to perfectly suit your needs. Our experts will work together with you on a custom-tailored setup. Typically, BRAVE B-Curious will be the base station. You add modules as you require – with the possibility of future upgrades and additional modules at a later date. For scale-up into 24/7 production monitoring, we also provide PAT sensors.
Time-resolved PSD and particle sizing
Allows the monitoring of PSD continuously and directly out of containers. Ideal for monitoring agglomeration, formation, dissolution, aggregation, dissociation, self-assembly and more. Size range: 50 nm* to 3 µm* (*sample-dependent)
Particle concentration and particle counts
Allows the detection of small particles from approx. 5 nm to 50 nm. Gives insight into agglomeration and aggregation behavior.
Allows the detection and sizing of large-particle tails, LPC, large aggregates and anomalies. Also for PFAT5 detection. Size range: 2 µm* to 80 µm* (*sample-dependent)
Allows the detection, identification and characterization of particle populations via Raman spectroscopy.
Modules for sample handling
To make your life easier, use the BRAVE modules for automatic sample handling and sample dilution.
For 24/7 production monitoring BRAVE Analytics provides custom-tailored online solutions.
Let us introduce you to H.A.N.S. (High-throughput Analysis Nano-characterization Software) installed on our BRAVE devices. H.A.N.S. is named after Hans, a lab technician at the Medical University of Graz who helped manually count particles during the early development phase (Thanks, Hans!). Just like the real Hans, the H.A.N.S. software is structured and straightforward. All workflows are intuitive to use. The software allows individual application and method development and comes with preset and definable device parameters.
The H.A.N.S. is responsible for three main control assets:
H.A.N.S. supports you with:
A continuous measurement in a lab instrument?
Single-particle sensitivity?
Additional small-particle or Raman analysis?
You’ve never heard of it before and yet the real-time insights from this new approach could save you money and greatly improve your particle processes. Check out how our BRAVE devices are helping these customers in research and industry. For more information, contact us or book a live demonstration and we will answer all your questions.
You are just one click away from revolutionizing your particle sizing!
A number of methods for particle characterization are available. These all have their advantages and disadvantages and are suited for different areas of application. BRAVE B-Curious with the patented OF2i® method has a number of advantages over conventional approaches.
Electron microscopes deliver impressive high-resolution images. Despite offering in-depth analysis, BRAVE B-Curious still has benefits compared to this method of particle analysis.
If you are used to analyzing particles with Dynamic Light Scattering, you can look forward to next-level results and benefits such as:
BRAVE ANALYTICS
Our expertise
As a partner in the MOZART project (MOZART for safe & sustainable by-design metallic coatings & engineered surfaces (RIA)), we received funding from the European Commission as part of the EU Horizon 2020 program.