BRAVE B-Continuous
Produce like never before & stay ahead of the game
Imagine what it would be like to revolutionize the production processes of your company like never before and to save time and resources as well as reduce out-of-spec production and increase efficiency. Too good to be true? We don’t think so.
BRAVE B-Continuous is the first true PAT sensor for real-time online nanoparticle characterization. It monitors particle size, number-based particle size distributions and particle concentration during production while delivering measurements directly to your network. Thanks to BRAVE B-Continuous, waiting for the results from samples sent to the lab is reduced to a minimum. This sensor lays the foundation for real-time release testing.
As BRAVE B-Continuous can be easily embedded into your production plant as a fully automated PAT sensor you can monitor your production continuously and in real-time. This way you obtain exact measurement data regarding particle size, number-based particle size distribution and particle concentration without the need to rely on sample analysis from the laboratory. With the continuous measurement data from BRAVE B-Continuous you can optimize and adapt your production constantly.
With BRAVE B-Continuous:
You can reduce rejects as you now have total control of the particle sizes and are able to continuously monitor and adjust them.
You don't need to wait for lab test results and can optimize your processes in real-time. Measurement data is visible on your network in a matter of seconds.
You obtain a better understanding of your production processes, as you constantly collect precious data for process optimization.
You are able to monitor the health of your production plant and carry out maintenance in good time.
You ensure the quality of your final product, as anomalies, aggregates and oversized particles will be identified.
You can integrate checks on the filtration and dilution systems
You establish a basis for RTRT (Real-Time Release Testing).
You can fully concentrate on your other duties knowing that your production is doing as it should and the quality of your product is guaranteed.
What does BRAVE B-Continuous measure?
Particle size measurement with single-particle sensitivity
Particle size distribution (with actual D-Values)
Particle concentration (down to a few particles per milliliter)
Large-particle tails, LPC, oversized particles and outliers
Full sizing histogram, even of complex polydisperse systems
Send us your sample – and we’ll do the rest
Find out whether OF2i® measurements are the answer to your particle challenges!
Get in touch, we’ll organize measurements on your sample(s) and send you a detailed measurement report.
This is the first (non-binding) step to a feasibility study. Open the door to deeper insights today!
The idea of monitoring particle sizes inline and/or online is not new – or easy to implement. In-process measurement means in-flow measurement, and this brings a number of challenges for the established methods of particle characterization, which rely on measuring Brownian motion to gain results (like Dynamic Light Scattering or Nanoparticle Tracking Analysis). There are three challenges inherent in in-process particle characterization that do not pose a problem for BRAVE B-Continuous.
BRAVE B-Continuous is suitable for many applications but in particular we see immense potential in the production of pharmaceuticals, cosmetics and in biotechnological applications. Being able to control and approve production in real-time will establish BRAVE B-Continuous as a real game changer for these industries.
All of these benefits are possible because OF2i ® our new, patented method for particle size measurement is not restricted by the limits set by Brownian motion. Instead OF2i® uses optofluidic forces and actively transfers momentum to nanoparticles by laser, so the intensity of the scattering and the movement of a single particle as well as the number of particles per transported volume can be measured by an ultramicroscope. This leads to significant advantages for the online measurement of particle size, particle size distribution and particle concentration compared to conventional methods for analyzing nanoparticles.
SPECS
Measures number-based, hydrodynamic particle size distribution
For nanosuspensions, nanoemulsions and colloidal formulations:
Measurement time specs:
CONNECTIONS FOR INSTALLATION
OPERATION AND APPLICATION REQUIREMENTS
Bypass continuous sampling:
LIST OF COMPONENTS
Back in the very early days of BRAVE Analytics, Christian Hill, now CEO and CTO, needed help counting the particles in many different samples so he enlisted the help of Hans, a lab technician at the Institute for Biophysics at the Medical University of Graz. As not everyone has a Hans to help, our nanoparticle devices now come with H.A.N.S. (High-Throughput Analysis Nano-Characterization Software). This software controls the PAT sensor and delivers measurement reports. H.A.N.S. has understandable workflows and intuitive interfaces as well as preset and definable device parameters for individual application and method development.
H.A.N.S. provides more:
Currently BRAVE B-Continuous is in testing in pilot plants at selected partners from different industries. The official product launch of BRAVE B-Continuous is scheduled for 2024. If you want to get ahead of the competition, contact us for information about collaboration and test installations. We are happy to hear from strategic partners to bravely move forward with us.
You are just one click away from revolutionizing your production!
Our expertise
As a partner in the MOZART project (MOZART for safe & sustainable by-design metallic coatings & engineered surfaces (RIA)), we received funding from the European Commission as part of the EU Horizon 2020 program.