An interview with Christian Hill was featured in a specialized e-book published by The Analytical Scientist magazine. Christian talks about our favorite force – OF2i – and how he sees its place in the world of particle analysis. Other contributions cover the use of ICP-TOFMS to detect complete elemental mass spectra from short transient events (such as single nanoparticles), the latest trends in cell and gene therapy analysis, how to achieve single-molecule detection and where the future challenges in nanoparticle analysis lie.